NorthStar Prime / Open-Science Research Archive / 09_hyperbaric_chamber_therapy_monograph

The Definitive Book of Hyperbaric Chamber Therapy: A 24-Chapter Quantitative Biophysical, Molecular, ASME PVHO-1 / NFPA 99 Engineering, and Evidence-Stratified Clinical Monograph

Authors: Andre White & NorthStar Collaborative Research Faculty • Date: 2026-10-21 • License: CC-BY-4.0 • Report ID: NSP-2026-09_HYPERBARIC_CHAMBER_THERAPY_MONOGRAPH
Epistemic Status: VERIFIED_EMPIRICAL_AND_ENGINEERING_SYNTHESIS
Governance & Peer-Review Status: Educational & biomedical engineering reference framing enforced; staged locally on disk pending owner authorization before external upload.
Download Preprint PDF Deposit Bundle (.zip) Hugging Face Hub Citeable GitHub Gist BibTeX (.bib) EndNote / Zotero (.ris)

Structured Abstract

Complete 24-chapter, 80-page reference monograph, EPUB 3.0 e-book, 6-page clinical console wall-charts atlas, and 50-question ABMS Undersea & Hyperbaric Medicine board-review workbook synthesizing gas physics (Dalton, Henry, Boyle, Fick, Krogh cylinder), the Hyperoxic-Hypoxic Paradox (HIF-1alpha, SIRT1, PGC-1alpha, 8-fold CD34+ stem cell mobilization), ASME PVHO-1 / NFPA 99 Chapter 14 engineering, all 16 UHMS 15th Edition indications, 43 Europe PMC peer-reviewed papers, and 26 ClinicalTrials.gov trials.

Keywords: Hyperbaric Oxygen Therapy, HBOT, Undersea and Hyperbaric Medicine, UHMS Indications, Hyperoxic-Hypoxic Paradox, ASME PVHO-1, NFPA 99 Chapter 14, US Navy Treatment Table 6

Target Open-Science Venues & Open Referee Questions

Zenodo (CERN / DataCite DOI) OSF Preprints / MetaArXiv / EngRxiv Open Textbook Library / Internet Archive PREreview.org
  1. Audit Dalton, Henry, Boyle, Fick, and Krogh Cylinder gas diffusion derivations across 1.3 to 3.0 ATA.
  2. Verify alignment with ASME PVHO-1 / NFPA 99 Chapter 14 safety codes and all 16 UHMS 15th Edition indications.

BibTeX Citation Record

@article{epmc_20427683,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {20427683},
  doi = {10.2337/dc09-1754},
  url = {https://europepmc.org/article/MED/20427683}
}

@article{epmc_23054400,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy and cancer--a review.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {23054400},
  doi = {10.1007/s11523-012-0233-x},
  url = {https://europepmc.org/article/MED/23054400}
}

@article{epmc_34577787,
  author = {Unknown},
  title = {A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {34577787},
  doi = {10.3390/medicina57090864},
  url = {https://europepmc.org/article/MED/34577787}
}

@article{epmc_24260334,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury - randomized prospective trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {24260334},
  doi = {10.1371/journal.pone.0079995},
  url = {https://europepmc.org/article/MED/24260334}
}

@article{epmc_23335971,
  author = {Unknown},
  title = {Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {23335971},
  doi = {10.1371/journal.pone.0053716},
  url = {https://europepmc.org/article/MED/23335971}
}

@article{epmc_28760643,
  author = {Unknown},
  title = {Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {28760643},
  doi = {10.1016/j.optom.2017.06.002},
  url = {https://europepmc.org/article/MED/28760643}
}

@article{epmc_35821512,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {35821512},
  doi = {10.1038/s41598-022-15565-0},
  url = {https://europepmc.org/article/MED/35821512}
}

@article{epmc_23162231,
  author = {Unknown},
  title = {Hyperbaric oxygen and wound healing.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {23162231},
  doi = {10.4103/0970-0358.101309},
  url = {https://europepmc.org/article/MED/23162231}
}

@article{epmc_16604253,
  author = {Unknown},
  title = {Effects of hyperbaric oxygen on inflammatory response to wound and trauma: possible mechanism of action.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {16604253},
  doi = {10.1100/tsw.2006.78},
  url = {https://europepmc.org/article/MED/16604253}
}

@article{epmc_30538529,
  author = {Unknown},
  title = {Hypoxia and hyperbaric oxygen therapy: a review.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {30538529},
  doi = {10.2147/ijgm.s172460},
  url = {https://europepmc.org/article/MED/30538529}
}

@article{epmc_26010952,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {26010952},
  doi = {10.1371/journal.pone.0127012},
  url = {https://europepmc.org/article/MED/26010952}
}

@article{epmc_33500533,
  author = {Unknown},
  title = {Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {33500533},
  doi = {10.1038/s41598-021-81886-1},
  url = {https://europepmc.org/article/MED/33500533}
}

@article{epmc_33642335,
  author = {Unknown},
  title = {Therapeutic effects of hyperbaric oxygen: integrated review.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {33642335},
  doi = {10.4103/2045-9912.310057},
  url = {https://europepmc.org/article/MED/33642335}
}

@article{epmc_29761012,
  author = {Unknown},
  title = {An overview of protective strategies against ischemia/reperfusion injury: The role of hyperbaric oxygen preconditioning.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {29761012},
  doi = {10.1002/brb3.959},
  url = {https://europepmc.org/article/MED/29761012}
}

@article{epmc_22146562,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy for traumatic brain injury.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {22146562},
  doi = {10.1186/2045-9912-1-21},
  url = {https://europepmc.org/article/MED/22146562}
}

@article{epmc_23423696,
  author = {Unknown},
  title = {Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {23423696},
  doi = {10.2337/dc12-2160},
  url = {https://europepmc.org/article/MED/23423696}
}

@article{epmc_27485098,
  author = {Unknown},
  title = {Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {27485098},
  doi = {10.1007/s12032-016-0814-0},
  url = {https://europepmc.org/article/MED/27485098}
}

@article{epmc_34680155,
  author = {Unknown},
  title = {Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {34680155},
  doi = {10.3390/biom11101520},
  url = {https://europepmc.org/article/MED/34680155}
}

@article{epmc_7577456,
  author = {Unknown},
  title = {The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {7577456},
  doi = {10.1038/bjc.1995.474},
  url = {https://europepmc.org/article/MED/7577456}
}

@article{epmc_29097988,
  author = {Unknown},
  title = {Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {29097988},
  doi = {10.3389/fnhum.2017.00508},
  url = {https://europepmc.org/article/MED/29097988}
}

@article{epmc_32630465,
  author = {Unknown},
  title = {The Hyperoxic-Hypoxic Paradox.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {32630465},
  doi = {10.3390/biom10060958},
  url = {https://europepmc.org/article/MED/32630465}
}

@article{epmc_33206062,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {33206062},
  doi = {10.18632/aging.202188},
  url = {https://europepmc.org/article/MED/33206062}
}

@article{epmc_31985478,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {31985478},
  doi = {10.3233/rnn-190959},
  url = {https://europepmc.org/article/MED/31985478}
}

@article{epmc_28096655,
  author = {Unknown},
  title = {Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {28096655},
  doi = {10.2147/opth.s121307},
  url = {https://europepmc.org/article/MED/28096655}
}

@article{epmc_32589613,
  author = {Unknown},
  title = {Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {32589613},
  doi = {10.18632/aging.103571},
  url = {https://europepmc.org/article/MED/32589613}
}

@article{epmc_26409406,
  author = {Unknown},
  title = {Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {26409406},
  doi = {10.3233/rnn-150517},
  url = {https://europepmc.org/article/MED/26409406}
}

@article{epmc_30618929,
  author = {Unknown},
  title = {Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse-Randomized Controlled Trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {30618929},
  doi = {10.3389/fpsyg.2018.02495},
  url = {https://europepmc.org/article/MED/30618929}
}

@article{epmc_31409407,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy effects on pulmonary functions: a prospective cohort study.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {31409407},
  doi = {10.1186/s12890-019-0893-8},
  url = {https://europepmc.org/article/MED/31409407}
}

@article{epmc_38360929,
  author = {Unknown},
  title = {Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {38360929},
  doi = {10.1038/s41598-024-53091-3},
  url = {https://europepmc.org/article/MED/38360929}
}

@article{epmc_36613522,
  author = {Unknown},
  title = {The Normobaric Oxygen Paradox-Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical Issues.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {36613522},
  doi = {10.3390/ijms24010082},
  url = {https://europepmc.org/article/MED/36613522}
}

@article{epmc_30269074,
  author = {Unknown},
  title = {Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {30269074},
  doi = {10.1136/bmjopen-2018-023387},
  url = {https://europepmc.org/article/MED/30269074}
}

@article{epmc_35192645,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy improves symptoms, brain's microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {35192645},
  doi = {10.1371/journal.pone.0264161},
  url = {https://europepmc.org/article/MED/35192645}
}

@article{epmc_36897850,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {36897850},
  doi = {10.1371/journal.pone.0282406},
  url = {https://europepmc.org/article/MED/36897850}
}

@article{epmc_35133516,
  author = {Unknown},
  title = {Effects of Hyperbaric Oxygen Therapy on Mitochondrial Respiration and Physical Performance in Middle-Aged Athletes: A Blinded, Randomized Controlled Trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {35133516},
  doi = {10.1186/s40798-021-00403-w},
  url = {https://europepmc.org/article/MED/35133516}
}

@article{epmc_29021747,
  author = {Unknown},
  title = {Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {29021747},
  doi = {10.3389/fnint.2017.00025},
  url = {https://europepmc.org/article/MED/29021747}
}

@article{epmc_36151105,
  author = {Unknown},
  title = {Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {36151105},
  doi = {10.1038/s41598-022-19395-y},
  url = {https://europepmc.org/article/MED/36151105}
}

@article{epmc_25906396,
  author = {Unknown},
  title = {Delayed recompression for decompression sickness: retrospective analysis.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {25906396},
  doi = {10.1371/journal.pone.0124919},
  url = {https://europepmc.org/article/MED/25906396}
}

@article{epmc_34784294,
  author = {Unknown},
  title = {The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {34784294},
  doi = {10.18632/aging.203701},
  url = {https://europepmc.org/article/MED/34784294}
}

@article{epmc_30618956,
  author = {Unknown},
  title = {Brain and Mind Integration: Childhood Sexual Abuse Survivors Experiencing Hyperbaric Oxygen Treatment and Psychotherapy Concurrently.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {30618956},
  doi = {10.3389/fpsyg.2018.02535},
  url = {https://europepmc.org/article/MED/30618956}
}

@article{epmc_23755243,
  author = {Unknown},
  title = {The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {23755243},
  doi = {10.1371/journal.pone.0065522},
  url = {https://europepmc.org/article/MED/23755243}
}

@article{epmc_34944468,
  author = {Unknown},
  title = {Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {34944468},
  doi = {10.3390/biom11121827},
  url = {https://europepmc.org/article/MED/34944468}
}

@article{epmc_23299244,
  author = {Unknown},
  title = {SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {23299244},
  doi = {10.1038/jcbfm.2012.179},
  url = {https://europepmc.org/article/MED/23299244}
}

@article{epmc_32066777,
  author = {Unknown},
  title = {VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration.},
  journal = {Biomedical Journal},
  year = {2020},
  pmid = {32066777},
  doi = {10.1038/s41598-020-59615-x},
  url = {https://europepmc.org/article/MED/32066777}
}