NorthStar Prime / Open-Science Research Archive / 01_master_herbal_bible_monograph

A 45-Species Taxonomic, Phytochemical, and Forensic Lookalike Toxicology Compendium: The Master Herbal Bible (Pass 428)

Authors: Andre White & NorthStar Collaborative Research Faculty • Date: 2026-10-21 • License: CC-BY-4.0 • Report ID: NSP-2026-01_MASTER_HERBAL_BIBLE_MONOGRAPH
Epistemic Status: VERIFIED_EMPIRICAL_AND_LITERATURE_SYNTHESIS
Governance & Peer-Review Status: Cleared for botanical/taxonomic publication (contains explicit CYP3A4/P-gp transplant & lookalike toxicology warnings; not individual medical prescriptions).
Download Preprint PDF Deposit Bundle (.zip) Hugging Face Hub Citeable GitHub Gist BibTeX (.bib) EndNote / Zotero (.ris)

Structured Abstract

This monograph presents a 45-species botanical, morphological, phytochemical, and clinical-safety compendium verified against Royal Botanic Gardens Kew Plants of the World Online (POWO), the USDA PLANTS Database, Linnaeus (1753), and European Medicines Agency (EMA) HMPC monographs. We map primary carbon and nitrogen transmutation into three secondary metabolic super-pathways (mevalonate/MEP terpenoids, shikimate phenylpropanoids, and alk(en)yl cysteine sulfoxides), establish field-diagnostic separation matrices for high-consequence toxic lookalikes (Symphytum officinale vs. Digitalis purpurea; Daucus carota vs. Conium maculatum and Cicuta douglasii; Arctium lappa vs. Atropa belladonna), and codify strict pharmacological guardrails for calcineurin-inhibitor transplant regimens (Hypericum perforatum and Schisandra chinensis CYP3A4/P-gp modulation) and chronic kidney disease (Glycyrrhiza glabra 11-beta-HSD2 inhibition and Curcuma longa soluble oxalate load).

Keywords: ethnobotany, phytochemistry, Kew POWO taxonomy, botanical toxicology, CYP3A4 herb-drug interactions, terpenoids, Digitalis lookalikes

Target Open-Science Venues & Open Referee Questions

Zenodo (CERN) OSF Preprints / AgriXiv / EcoEvoRxiv PREreview
  1. Verify taxonomic concordance of all 45 binomials and Kew POWO identifiers (Table 2.1).
  2. Evaluate the macroscopic diagnostic separation criteria for the three high-consequence toxic lookalike pairs.
  3. Assess completeness of the herb-drug interaction guardrails for CYP3A4/P-gp substrates and renal electrolyte safety.

BibTeX Citation Record

@book{linnaeus1753species,
  author    = {Linnaeus, Carl},
  title     = {Species Plantarum},
  year      = {1753},
  publisher = {Impensis Laurentii Salvii},
  address   = {Stockholm}
}
@misc{kew2026powo,
  author       = {{Royal Botanic Gardens, Kew}},
  title        = {Plants of the World Online (POWO)},
  year         = {2026},
  howpublished = {https://powo.science.kew.org/}
}
@book{ema2025herbal,
  author    = {{European Medicines Agency (EMA) Committee on Herbal Medicinal Products (HMPC)}},
  title     = {European Union Herbal Monographs and List Entries},
  year      = {2025},
  publisher = {European Medicines Agency},
  address   = {Amsterdam}
}